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Oxidative modifications of metabolic enzymes
代谢酶的氧化还原修饰模式
In response to ROS-mediated oxidative stress, many metabolic enzymes can undergo redox modifications, including glycolytic enzymes (HK1, TPI, GAPDH, ENO, PKM2, and PDHK2, etc.), TCA cycle enzymes (Aconitase, PDHK2, etc.), lipid metabolism enzymes (ACAT2, TPβ, etc.), energy metabolism enzymes (AMPK, CK, etc.), and amino acid metabolism enzymes (CBS, etc.), leading to the alteration of metabolic patterns.
