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. 2022 Nov 20;53(6):1127–1134. [Article in Chinese] doi: 10.12182/20221160302

表 1. Potential therapeutic strategies for alleviating RIHD.

缓解放射性心脏损伤的潜在治疗对策

Strategy Mechanism Result
 MSCs: Mesenchymal stem cells; MMPs: Matrix metalloproteinases; RAAS: Renin-angiotensin-aldosterone system; +: Positive result; −: Negative result.

Pentoxifylline and α-tocopherol[42], Amifostine[43], black grape juice[44], Hydrogen-rich water[45], melatonin[46], hesperidin[47], lycopene[48]

Antioxidant +
Statins [49- 50] Lower cholesterol +, −
IPW-5371[51] Inhibit TGF-β receptor 1 +
MSCs[52] Promote DNA repair +
Captopril[53] Inhibit the RAAS system +
Dexrazoxane[54] Anti-apoptotic +
Colchicine[55]

Anti-inflammatory and anti-coagulant

+
Huangqi Shengmai Yin[56]

Regulate TGF-β1/Smads and MMPs

+