表 1. Potential therapeutic strategies for alleviating RIHD.
Strategy | Mechanism | Result |
MSCs: Mesenchymal stem cells; MMPs: Matrix metalloproteinases; RAAS: Renin-angiotensin-aldosterone system; +: Positive result; −: Negative result. | ||
Pentoxifylline and α-tocopherol[42], Amifostine[43], black grape juice[44], Hydrogen-rich water[45], melatonin[46], hesperidin[47], lycopene[48] |
Antioxidant | + |
Statins [49- 50] | Lower cholesterol | +, − |
IPW-5371[51] | Inhibit TGF-β receptor 1 | + |
MSCs[52] | Promote DNA repair | + |
Captopril[53] | Inhibit the RAAS system | + |
Dexrazoxane[54] | Anti-apoptotic | + |
Colchicine[55] |
Anti-inflammatory and anti-coagulant |
+ |
Huangqi Shengmai Yin[56] |
Regulate TGF-β1/Smads and MMPs |
+ |