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. 2023 Aug 8;21(8):e3002214. doi: 10.1371/journal.pbio.3002214

Fig 5. The ERF versus the number, n, of positions in the viral genome giving rise to concerning (or viable) mutations.

Fig 5

The ERF of mutagenic treatment is the ratio of the cumulative mutant virus load with and without treatment. We explore all values of n subject to the constraint that m+n remains below the length of the SARS‑CoV‑2 genome. We observe that the ERF decreases as function of n. (A) Treatment starts at peak virus load. (B) Treatment starts at infection. Parameters: a0 = 3 per day, b = 7.61 per day, u0 = 10−6 per bp, u1 = 3∙10−6 per bp, T = 5 days. Initial condition: x0 = 1 and y0 = 0. The code used to generate this figure can be found at DOI: 10.5281/zenodo.8017992. ERF, evolutionary risk factor; SARS‑CoV‑2, Severe Acute Respiratory Syndrome Coronavirus 2.