Table 2. Cumulative virus load, mutant load, IRF, and ERF of mutagenic treatment.
| Value of a1 | Cumulative mutant viral load with no treatment Y00 (×1,000) | Cumulative mutant viral load with treatment Y01 (×1,000) | Evolutionary risk factor Y01/Y00 | Cumulative viral load with no treatment V00 (×109) | Cumulative viral load with treatment V01 (×109) | Infectivity risk factor V01/V00 |
|---|---|---|---|---|---|---|
| Treatment starts at peak virus load | ||||||
| 7.69 | 1,488 | 758 | 0.51 | 21.9 | 10.3 | 0.47 |
| 7.76 | 1,030 | 634 | 0.62 | 17.0 | 9.2 | 0.54 |
| 7.92 | 596 | 458 | 0.77 | 11.5 | 7.5 | 0.65 |
| 8.07 | 428 | 363 | 0.85 | 8.9 | 6.4 | 0.72 |
| 8.76 | 197 | 191 | 0.97 | 4.8 | 4.1 | 0.86 |
| Treatment starts at infection | ||||||
| 7.69 | 1,488 | 343 | 0.23 | 21.9 | 2.4 | 0.11 |
| 7.76 | 1,030 | 297 | 0.29 | 17.0 | 2.1 | 0.13 |
| 7.92 | 596 | 228 | 0.38 | 11.5 | 1.7 | 0.15 |
| 8.07 | 428 | 189 | 0.44 | 8.9 | 1.5 | 0.17 |
| 8.76 | 197 | 112 | 0.57 | 4.8 | 1.0 | 0.20 |
We show numerical results for individuals that differ in their immune competence, which affects the clearance rate, a1, during adaptive immunity. Patients that are less immunocompetent benefit more from mutagenic treatment (lower IRF) and also have a lower ERF. Parameters: a0 = 3 per day, b = 7.61 per day, u0 = 10−6 per bp, u1 = 3∙10−6 per bp, m = 20,000, n = 1, T = 5 days. Initial condition: x0 = 1 and y0 = 0.
ERF, evolutionary risk factor; IRF, infectiousness risk factor.