TABLE 2.
Individual humoral immune responses at challenge
| Study group or statistical test | Animal | Antibody titer
|
Infection status | ||
|---|---|---|---|---|---|
| gp120 | HIV-1SF2a | SHIVSF13a | |||
| Study groups | |||||
| gp120/DNA | I038 | 12 | <10 | <10 | Infected |
| Q062 | <10 | <10 | <10 | Infected | |
| I044 | 35 | 10 | <10 | Infected | |
| X007 | 34 | <10 | <10 | Infected | |
| rgp120/MF59 | I046 | 857 | 67 | 10 | Transient infection |
| T118 | 1,976 | 150 | 10 | Transient infection | |
| J041 | 2,426 | 450 | 50 | Transient infection | |
| Z64 | 2,700 | 412 | 50 | Transient infection | |
| rgp120/ISCOM | T122 | 491 | 142 | 50 | Protected |
| L159 | 1,432 | ±10 | 50 | Transient infection | |
| Q048 | 3,227 | 56 | <10 | Transient infection | |
| X009 | 3,191 | ±10 | <10 | Protected | |
| DNA controls | Q045 | <10 | NDb | ND | Infected |
| Q054 | <100 | ND | ND | Infected | |
| Subunit controls | EP4 | <10 | ND | ND | Infected |
| WK2 | <10 | ND | ND | Infected | |
| Statistical tests | |||||
| Kruskal-Wallisc | 11.625 | 8.283 | ND | ||
| P value | <0.05 | <0.02 | ND | ||
| ISCOM vs MF59 | |||||
| Wilcoxond | 7 | 1 | ND | ||
| P value | NSe | 0.1 > P > 0.05 | ND | ||
NA titers.
ND, not determined.
Statistical analysis to determine whether there was a significant difference between groups.
Statistical analysis to determine whether there was a significant difference between the two protein subunit groups.
NS, not significant.