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. Author manuscript; available in PMC: 2024 Oct 1.
Published in final edited form as: Neuropharmacology. 2023 Jun 5;237:109601. doi: 10.1016/j.neuropharm.2023.109601

Fig. 1.

Fig. 1.

Dose response of LY2828360 in suppressing carrageenan-induced mechanical allodynia in female C57 WT mice (n = 6 per group). LY2828360 reduced carrageenan-induced mechanical allodynia at a dose of 10 mg/kg i.p. but not at lower doses (1 or 3 mg/kg i.p.). LY2828360 (10 mg/kg) increased paw withdrawal thresholds in the ipsilateral paw (A) but not the contralateral paw (B) in a mouse model of carrageenan-induced inflammatory pain. Data show mean (± SEM) threshold for the ipsilateral and contralateral paw in Experiment 1. *p < 0.05 vs. VEH; ###p < 0.001 vs. baseline (BL).