Figure 8. Hypothesized mechanisms of GABA co-transmission increase in DAT::NrxnsKO mice.

(A) Illustration of the first hypothesis showing an increase of vesicular monoamine transporter (VMAT2) expression in DAT::NrxnsKO neurons, allowing increased vesicular GABA packaging. (B) Illustration of the second hypothesis showing an increase of GABA uptake through GAT1/4 in DAT::NrxnsKO neurons. (C) Illustration of the third hypothesis showing a possible loss of interaction between the presynaptic Nrxns and postsynaptic GABA_A receptors.