FIG. 1.

Clinical, virologic, and serologic responses in Ch1535 (A and B) and Ch1536 (C and D) following inoculation with RNA transcripts representing the HCV infectious clone. (A and C) Serum RNA, ALT, and inflammatory responses (numbers across the top of the graph), graded from 0 to 4 (representing none, minimal, mild, moderate, and marked). (B and D) Antibody responses to recombinant E1E2 antigen (open squares) and positivity in commercial EIAs [EIA (+)]. Anti-E1E2 antibody responses are represented as P/N ratios, with the cutoff of 2 (twice the value of the preserum sample) indicated by the dotted line.