Abstract
Topically applied anaesthetics may lead to a serious keratopathy. Three patients presented to us with disciform keratitis, peripheral corneal ring, and stromal infiltration following the topical use of oxybuprocaine. All three patients developed marked decrease in vision secondary to corneal scarring. In all three patients oxybuprocaine was dispensed over the counter by a pharmacist. Legislation for the restriction of over-the-counter sale of topical anaesthetics, steroids, and antibiotics is essential in the prevention of many of the self-induced ocular disorders seen in developing countries.
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- Adenis J. P., Merle L., Dangoumau J., Robin A., Nicot G. Problèmes posés par l'utilisation des collyres et pommades anesthésiques en ophtalmologie. Therapie. 1978 Nov-Dec;33(6):791–795. [PubMed] [Google Scholar]
- Epstein D. L., Paton D. Keratitis from misuse of corneal anesthetics. N Engl J Med. 1968 Aug 22;279(8):396–399. doi: 10.1056/NEJM196808222790802. [DOI] [PubMed] [Google Scholar]
- Henkes H. E., Waubke T. N. Keratitis from abuse of corneal anaesthetics. Br J Ophthalmol. 1978 Jan;62(1):62–65. doi: 10.1136/bjo.62.1.62. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Henrotte J., Weekers J. F. Etude clinique des lésions cornéennes dues à l'application locale et prolongée d'anesthésiques. Arch Ophtalmol Rev Gen Ophtalmol. 1972 Jun-Jul;32(6):449–456. [PubMed] [Google Scholar]
- Hilsdorf C., Zenklusen G. Novesinschäden der Hornhaut. Klin Monbl Augenheilkd. 1973 Apr;162(4):525–527. [PubMed] [Google Scholar]
- Jallet G., Cleirens S., Girard E., Béchetoille A. Kératopathie toxique grave à l'oxybuprocaine d'apparition particulierement rapide. Bull Soc Ophtalmol Fr. 1980 Apr-May;80(4-5):385–387. [PubMed] [Google Scholar]
- Klíma M., Rückerová H. Tezké poskození oka Novesinem. Cesk Oftalmol. 1974 Sep;30(5):375–380. [PubMed] [Google Scholar]
- Smith R. B., Everett W. G. Physiology and pharmacology of local anesthetic agents. Int Ophthalmol Clin. 1973 Summer;13(2):35–60. [PubMed] [Google Scholar]
- Weekers J. F. Recherches expérimentales sur la genése des lésions cornéennes dues aux anesthésiques. Arch Ophtalmol Rev Gen Ophtalmol. 1974 Feb;34(2):121–132. [PubMed] [Google Scholar]
- van Rij G., Renardel de Lavalette J. G., Baarsma G. S., Jansen J. T. Effect of oxybuprocaine 0.4% in preventing surgically induced miosis. Br J Ophthalmol. 1984 Apr;68(4):248–251. doi: 10.1136/bjo.68.4.248. [DOI] [PMC free article] [PubMed] [Google Scholar]