TABLE 2.
Susceptibility of neural cell lines to acute and persistent infection by HuCV 229E
| Cell line
|
Infectiona
|
||
|---|---|---|---|
| Designation | Phenotype | Acute | Persistent |
| U-87 MG | Astrocytoma | 1+ | − |
| U-373 MG | Astrocytoma (grade III) | 1+ | − |
| GL-15 | Astrocytic (glioblastoma multiforme positive for glial fibrillary acidic protein marker) | 2+ | − |
| MO3.13 | Oligodendrocytic (adult oligodendrocyte fused with a rhabdosarcoma) | 2+ | 2+ |
| CHME-5 | Microglial (fetal microglia transfected with large T antigen of simian virus 40) | − | − |
| H4 | Neuroglial (ganglioglioma) | 2+ | 1+ |
| SK-N-SH | Neuroblastoma | 3+ | − |
a
Results obtained from an indirect immunofluorescence assay and an infectious virus titer assay. −, noninfectable or no persistence after fifth passage; +, <10% of cells infected; 2+, between 10 and 50% of cells infected; 3+, >50% of cells infected.