TABLE 3.

Characterization of sequence changes detected in the S1 region of the surface glycoprotein during persistent HuCV-229E infection

Cell line(s)	Infection	Position of point mutationa	Codon change	Amino acid change
L-132, H4, and MO3.13	Acute and persistent	727ab	TGT→TTT	C→F
L-132	Persistent (passage 42)	571a	ACT→ATT	T→I
H4	Persistent (passage 48)
MO3.13	Persistent (passage 40)	571a	ACT→ATT	T→I
		592a	GCA→GTA	A→V

^aReference 55. 

^bReference 28a; ATCC strain.