TABLE 2.

Susceptibility of neural cell lines to acute and persistent infection by HuCV-OC43

Cell line		Infectiona
Line designation	Phenotype	Acute	Persistent
U-87 MG	Astrocytoma	2+	2+
U-373 MG	Astrocytoma (grade III)	2+	2+
GL-15	Astrocytic (glioblastoma multiforme, positive for glial fibrillary acidic protein marker)	1+	−
MO3.13	Oligodendrocytic (adult oligodendrocyte fused with a rhabdosarcoma)	2+	3+
CHME-5	Microglial (fetal microglia transfected with large T antigen of simian virus 40)	1+	−
H4	Neuroglial (ganglioglioma)	2+	2+
SK-N-SH	Neuroblastoma	2+	−

^aResults obtained from an indirect immunofluorescence assay and an infectious virus titer assay. −, noninfectable or no persistence after fifth passage; 1+, <10% of cells infected; 2+, between 10 and 50% of cells infected; 3+, >50% of cells infected.