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. 2023 Jun 23;16(5):497–513. doi: 10.1007/s40271-023-00635-w

Table 5.

Trade-offs (marginal rates of substitution) and marginal willingness-to-pay estimates for MMNL model

Marginal willingness-to-pay estimates Mean 95% CI Interpretation
Respondent characteristic Attribute
Respondents with low-income ≤ AU$87,999 per year Risk of recurrence at 3 years – 794.032 −1745.15 to 740.70 Respondents with lower income were, on average, willing to pay an extra AU$795 (95% CI – AU$741 to AU$1745) per year for each 1% reduction in their absolute risk of recurrence at 3 years with adjuvant immunotherapy
Respondents with high-income ≥ AU$88,000 per year Risk of recurrence at 3 years – 2189.55 – 4571.05 to 1650.90 Respondents with higher income were, on average, willing to pay an extra AU$2190 (95% CI – AU$1651 to AU$4571) for each 1% reduction in their absolute risk of recurrence at 3 years with adjuvant immunotherapy
Respondents with low-income ≤ AU$87,999 per year Risk of a fatal adverse event (AE) – 1530.73 – 8416.53 to 1527.40 Respondents with lower income were, on average, willing to pay AU$1531 (95% CI – AU$1527 to AU$8417) for a 1% lower chance of fatal AE
Respondents with high-income ≥ AU$88,000 per year Risk of a fatal AE – 4265.71 – 13,997.35 to 3484.34 Respondents with higher income were, on average, willing to pay AU$4266 (95% CI – AU$3484 to AU$13,997) for a 1% lower chance of fatal AE
Marginal rates of substitution estimates
 Risk of recurrence at 3 years ÷ risk of a permanent AE – 4.42 – 23.41 to 10.44 Respondents were willing to accept an additional 4% chance of a permanent AE to reduce their absolute risk of recurrence at 3 years by 1% (95% CI – 10.44 to 23.41)
 Risk of a fatal AE ÷ risk of recurrence at 3 years – 1.81 – 34.54 to 12.35 Respondents were willing to accept an additional 2% chance of recurrence at 3 years to lower their chance of a fatal AE by 1% (95% CI – 12.35 to 34.54)