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. 2023 Aug 8;14:4755. doi: 10.1038/s41467-023-40154-8

Fig. 2. Monitored haemodynamic indices and tissue ATP and glycogen during long-term perfusion of human split livers.

Fig. 2

Using a pressure-controlled system with a goal of 60 mmHg for the hepatic artery, the ERG and LLSG typically achieved 200 ml/min of blood flow (A, B). After adjustment for liver weight, the LLSG achieved significantly higher flows/min/kg of liver than the ERG (median 316 ml/min [IQR 224–613 ml/min] vs 126 ml/min [IQR 72–209 ml/min], p = 0.003, at 4 h after splitting, Mann–Whitney U Test) (C) (n = 20 partial livers; 10 ERGs, 10 LLSGs, expressed as median (IQR)). With a goal of 8 mmHg for the portal vein, the ERG and LLSG typically achieved 1.0 L/min and 300–400 ml/min, respectively (D, E). After adjustment for liver weight, the portal vein flow was similar between ERG and LLSGs (F) (n = 20 partial livers; 10 ERGs, 10 LLSGs, expressed as median (IQR)). Hepatic tissue ATP and glycogen levels remained stable or increased during perfusion in both ERGs and LLSGs compared to baseline (G, H). ATP adenosine triphosphate, ERG extended right graft, LLSG left lateral segment graft, *p < 0.05.