Table 2.

Differentially abundant proteins across contact lens (CL) experiments

Protein	Gene name	Fold changes in CL users
		CL Expt 1	CL Expt 2
Beta-1,3-galactosyl-O-glycosyl-
glycoprotein beta-1,6-N-	GCNT	+ 1.9	+ 1.6
acetylglucosaminyltransferase 3
Corneodesmosin	CDSN	+2.1	+ 1.9
Cystatin-SA	CST2	+ 11.3	-2.6
Desmocollin-1	DSC1	+2.1	+ 1.9
Desmoglein-1	DSG1	+2.0	+ 1.7
Desmoplakin	DSP	+2.2	+1.6
Loricrin	LRN	+2.0	+2.4
Mesothelin, cleaved form	MSLN	+1.9	+ 1.7
Polymeric immunoglobulin receptor	PIGR	+1.8	+2.3
Immunoglobulins, 14	See below *	+1.6 to +2.5	+ 1.8 to +2.9

Differential abundance was determined using the uncorrected edgeR p values in these CL analyses. CL Experiment 1 included a wide range of Schirmer strip wetted length, while CL Experiment 2 included samples from a restricted range of Schirmer strip wetted length. Bolded gene names represent proteins that were also elevated in a larger CL comparison with restricted Schirmer strip wetted length using IRS normalization (described below).

^*14 specific Immunoglobulins were more abundant with CL use: IGHA1, IGHV3–11, IGHV3–49, IGHV3–53, IGHV3–7, IGHV3–74, IGHV4–28, IGHV5–51, IGHV6–1, IGKV1–27, IGKV3–11, IGLV1–44, IGLV3–19, IGLL5