TABLE 1.

S envelope protein mutant phenotypes

WT and S mutant designation	Concn of:
	S protein (ng/ml of culture medium)	HDV RNA (pg/ml of culture medium)	HDV RNA (pg normalized to 80 ng of S protein)
WT	80	100	100
EN	0	0	NAa
S-222	33	14	34
S-212	7.5	0	NA
S-202	6	0	NA
S-192	0	0	NA
S-182	0	0	NA
S-172	1.5	0	NA
S-162	0	0	NA
Δ164-168KL	0	0	NA
Δ169-173KL	0	0	NA
Δ174-178KL	63	17.5	22
Δ179-183KL	57	3.5	5
Δ184-188GA	32	11.5	29
Δ189-193KL	30	11.5	30
Δ194-198GA	60	1	1.5
Δ199-203KL	44	5.5	10
Δ204-208KL	64	15	19
Δ209-213GA	80	27	27
Δ214-218KL	17	39	183
Δ219-223KL	0	0	NA
Δ195-197AAA	80	1.5	1.5
W196F	80	1.5	1.5

^aNA, not applicable.