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. 2023 Jun 12;30:235–245. doi: 10.1016/j.omtm.2023.06.005

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© 2023 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

LNP mRNA systems containing 40 mol % ESM exhibit longer circulation lifetimes following i.v. administration than Onpattro-type formulations

DiD-labeled LNP GFP mRNA were administered at a dose of 1.5 mg mRNA/kg and blood was collected via the saphenous vein at 0, 1.5, 4, 8, and 24 h. The circulating LNP levels were determined by measuring the DiD fluorescent intensity from collected blood. Each data point represents the arithmetic mean ± SD of data collected from five mice. (A) LNP GFP mRNA systems with the Onpattro lipid composition (DSPC/MC3/Chol/PEG-lipid 10:50:38.5:1). (B) LNP GFP mRNA systems containing 40 mol % ESM (ESMMC3/Chol/PEG-lipid 40:33:25.5:1.5).