TABLE 3.
Comparison of nucleotide and amino acid changes in genes and encoded proteins of influenza viruses
| Virus host and/or geographic locationa | Gene | Analyzed coding region | Mean no. of nucleotide changes ± SE | Mean no. of amino acid changes ± SE | Mean % of AAC/ NCb ± SE |
|---|---|---|---|---|---|
| Chicken, Hong Kongc | HA1 | 77–1042 | 6.8 ± 3.6 | 0.6 ± 0.5 | 5.9 ± 5.2 |
| Human, Hong Kongd | 77–1042 | 9.5 ± 2.9 | 5.0 ± 2.4 | 50.5 ± 18.7 | |
| Chicken, Mexicoe | 77–1042 | 40.8 ± 19.1 | 20.9 ± 10.1 | 57.3 ± 16.7 | |
| Chicken, Pennsylvaniaf | 77–1042 | 5.0 | 3.0 | 60.0 | |
| Duckg | 77–1042 | 41.5 ± 12.5 | 5.6 ± 0.8 | 15.1 ± 3.4 | |
| Chicken, Hong Kongc | NA | 64–1381 | 11.6 ± 5.9 | 4.2 ± 2.1 | 36.6 ± 6.4 |
| Chicken, Mexicoe | 64–1381 | 12.0 ± 9.3 | 3.6 ± 2.7 | 37.9 ± 25.9 | |
| Chicken, Hong Kongc | PB2 | 34–2304 | 16.5 ± 9.6 | 7.0 ± 3.6 | 46.9 ± 14.8 |
| Chicken, Mexicoe | 34–2304 | 22.2 ± 18.1 | 5.4 ± 4.4 | 24.3 ± 0 | |
| Avianh | 34–2304 | 294.7 ± 58.2 | 12.3 ± 4.1 | 4.9 ± 2.3 | |
| Chicken, Hong Kongc | PB1 | 34–2238 | 17.4 ± 11.9 | 4.2 ± 2.9 | 25.3 ± 10.9 |
| Chicken, Mexicoe | 34–2238 | 25.8 ± 21.1 | 3.6 ± 2.8 | 14.0 ± 0 | |
| Aviani | 34–2238 | 96.3 ± 7.4 | 2.0 ± 0 | 2.1 ± 0.1 | |
| Chicken, Hong Kongc | PA | 25–2172 | 13.1 ± 9.6 | 4.5 ± 2.7 | 51.3 ± 30.7 |
| Chicken, Mexicoe | 25–2172 | 24.4 ± 19.2 | 10.6 ± 8.5 | 41.3 ± 6.7 | |
| Avianj | 25–2172 | 71.0 ± 20.8 | 10.0 ± 2.5 | 10.6 ± 4.6 | |
| Chicken, Hong Kongc | NP | 46–1542 | 9.7 ± 5.7 | 2.7 ± 1.2 | 35.5 ± 21.8 |
| Chicken, Mexicoe | 46–1542 | 12.2 ± 9.6 | 0.6 ± 0.4 | 5.0 ± 0 | |
| Aviank | 46–1542 | 72.0 ± 9.0 | 3.0 ± 1.2 | 4.3 ± 2.2 |
With the exception of those viruses classified as avian, all viruses compared were of the H5 subtype.
AAC/NC, amino acid changes per nucleotide changes.
CHK258-97, DHK46-97, CHK915-97, CHK283-97, CHK786-97, and GHK355-97.
HK156, A/Hong Kong/481/97 (H5N1), A/Hong Kong/482/97 (H5N1), and A/Hong Kong/483/97 (H5N1).
CMEX94, CHID94, CPUE1-94, CPUE2-94, and CQUE95.
A/Chicken/Pennsylvania/1/83 (H5N2) and A/Chicken/Pennsylvania/1370/83 (H5N2).
DHK205-77, Dk/HK/342/78, DHK698-79, and DP84.
A/Budgerigar/Hokkaido/1/77 (H4N6), A/Ruddy Turnstone/New Jersey/47/85 (H4N6), A/Turkey/Minnesota/833/80 (H4N2), and A/Mallard/New York/6750/78 (H2N2).
A/Turkey/Minnesota/833/80 (H4N2), A/Mallard/New York/6750/78 (H2N2), and A/Gull/Maryland/704/77 (H13N6).
A/Pintail/Alberta/119/79 (H4N6), A/Turkey/Minnesota/833/80 (H4N2), A/Ruddy Turnstone/New Jersey/47/85 (H4N6), and A/Duck/Hokkaido/8/80 (H3N8).
DHK205-77, DHK698-79, A/Duck/Hong Kong/7/75 (H3N2), and A/Duck/Beijing/1/78 (H3N6).