Figure 1.

Cell-type markers heatmap. A Heatmap of TPM Z scores (percentile capped TPM at 5th and 95th) for cell-type marker genes is presented. Cell types included are skin cells (fibroblasts, keratinocytes, neural cells, melanocytes, endothelial) and immune cells (macrophage, mast cells, dendritic cells, multiple types of T cells, B cells, neutrophils). Cell cycling markers, collagens, and top 10 DEGs from the keloid baseline signature were also included as references. KE_baseline signature and a subset of collagens were upregulated in keloid tissue. Fibroblast markers closely follow the same pattern. Biological sex, race, and biopsy type are indicated in the figure column header. DEG, differentially expressed gene; K, keratin; TPM, transcripts per million.