Figure 11.

Immunohistochemistry of COL2A1 in healthy skin and ear keloids. (a) Boxplots of TPM values of COL2A1, COL10A1, and MMP9 across comparison groups, colored by tissue type. The y-axis is in log scale. (b) Formalin-fixed, paraffin-embedded specimens from keloid (top, n = 4) or abdominoplasty (bottom, n = 4) were subject to immunohistochemical colocalization of Col2 (red), Col1 (green), and α-SMA (blue). Col2 and subcellular Col1 were found exclusively in keloid, although they were associated with different cells. Bar = 50 μm. α-SMA, α-smooth muscle actin; Col1, collagen type 1; Col2, collagen type 2; MMP9, matrix metalloproteinase 9; TPM, transcripts per million.