Figure 7.

Keloid and wound-healing signature overlaps reveal keloid-associated gene sets. (a) Total number of DEGs (adjusted P-value < 0.05 and fold change > 1.5) in each group compared with those of their respective control groups, split by direction of change. (b) Upset plot summarizing the overlap of signatures in a. Upper panel bar plots: Each vertical bar shows the subset of DEGs that is significant across all the groups with filled-in black bubbles in the column directly below the bar. The proportions of this subset of genes that are upregulated across all indicated groups are represented by the red part of the bar: downregulated genes in blue and inconsistent genes in green. Lower panel: Keloid groups are highlighted in purple. Potentially developing keloid group is highlighted in gray. The red box and arrow indicate the DEG subset significant in all lesional and wound-healing groups, defined as the shared wound healing signature. Purple boxes and arrows indicate the DEG subsets only significant in keloid groups, defined as a keloid-associated signature. DEG, differentially expressed gene; F, female; M, male.