Table 6.

Risk assessments of the three markers based on tumor pathology

Variable	Pathology			P
	Benign	borderline	malignant
Pre-menopause
CA-125
Low risk	71 (66.40)	8 (88.90)	3 (16.60)	<0.0001
High risk	36 (33.60)	1 (11.10)	19 (86.40)
He4
Low risk	104 (97.20)	9 (100.00)	4 (18.20)	<0.0001
High risk	3 (2.80)	0 (0.00)	18 (81.80)
ROMA
Low risk	103 (96.30)	9 (100.00)	2 (9.10)	<0.0001
High risk	4 (3.70)	0 (0.00)	20 (90.90)
Post-menopause
CA-125
Low risk	28 (75.70)	5 (100.00)	0 (0.00)	<0.0001
High risk	9 (24.30)	0 (0.00)	21 (100.00)
He4
Low risk	37 (100.00)	5 (100.00)	3 (14.30)	<0.0001
High risk	0 (0.00)	0 (0.00)	18 (85.70)
ROMA
Low risk	36 (97.30)	5 (100.00)	2 (9.50)	<0.0001
High risk	1 (2.70)	0 (0.00)	19 (90.50)
Total
CA-125
Low risk	101 (69.20)	13 (92.90)	3 (7.00)	<0.0001
High risk	45 (30.80)	1 (7.10)	40 (93.00)
He4
Low risk	141 (97.90)	14 (100.00)	7 (16.30)	<0.0001
High risk	3 (2.10)	0 (0.00)	36 (83.70)
ROMA
Low risk	139 (96.50)	14 (100.00)	4 (9.30)	<0.0001
High risk	5 (3.50)	0 (0.00)	39 (90.70)