Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Jul 26;14:1219324. doi: 10.3389/fneur.2023.1219324

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2023 Muthusamy, Sivadasan, Dixon, Sudhakar, Thomas, Danda, Wszolek, Wierenga, Dhamija and Gavrilova.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

MRI features of hypomyelinating leukodystrophies. MRI features of an adolescent with spastic ataxic syndrome due to PMLD with T2 axial at 1 year (A) and 7 years (B, C) show near complete absence of myelination on the initial scan with no progression on the second scan. Note the diffuse pontine involvement in image C which is more common in PMLD than PMD.T1 axial image (D) shows hypo intensity of the white matter except in centrum semiovale. 18 q-syndrome in a 15 year old; T2 axial (E) shows reduced myelination than expected for age with a washed out appearance on FLAIR (F) but the preservation of hyperintensity on T1 images (G). Combination of these signal abnormalities on various sequences is highly suggestive of hypomyelination. MRI brain findings of an individual with POLR3-related hypomyelination with T2 (H), T1 (I), and FLAIR (J) axial images showing diffuse hypomyelination with sparing optic radiations and patchy myelin islands. T2 also shows hypo intensity of ventrolateral thalamus due to the relative preservation of myelin.