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. 2023 Jul 26;14:1219324. doi: 10.3389/fneur.2023.1219324

Figure 2.

Figure 2

MRI brain spectrum in adult-onset Krabbe disease. T2 axial FLAIR sequences (A–D) and T2 coronal (E) of a 36-year-old male with the subacute onset and progressive spasticity due to Krabbe disease demonstrate symmetric signal changes in the motor cortex extending downward along the corticospinal tract in the perirolandic region, posterior limb of the internal capsule (C) and pons (D), and garland-like appearance of the CST demonstrated in the coronal image [arrows in (E)]. Note the absence of splenial and adjacent parietooccipital white matter involvement (E). T2 FLAIR axial (F–I) and T2 sagittal FLAIR (J) of another individual with late-onset Krabbe disease demonstrate similar findings along with additional splenial and parieto-occipital white matter involvement [arrows in (H, J)].