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Acetate and formate cross-feeding between B. hydrogenotrophica and F. prausnitzii. The metabolism of B. hydrogenotrophica centers on glycolysis and the acetate pathway. The metabolism of F. prausnitzii centers on glycolysis and the formate and butyrate pathways. The key enzyme in butyrate production is butyryl-CoA:acetate CoA-transferase (ButCoAT). In red are the SCFAs consumed (acetate, formate). In blue are the SCFAs produced (acetate, butyrate). In green are the sugars consumed.
