Figure 4.

Graphic summary of relationships between Faecalibacterium representation within the intestinal microbiota and colon inflammation. The normal state of the microbiota greatly contrasts with the dysbiosis often encountered in digestive diseases such as IBD. Intestinal inflammation is accompanied by an overproduction of ROS as well as an increase in O₂ levels, conditions that favour facultative anaerobes over strict aerobes such as Faecalibacterium. In some patient cohorts, abundance of F. duncaniae A2-165 decreases while that of F. longum L2-6 increases (Song et al. 2016, Zhang et al. 2018).