FIG. 5.

Induction of the rAAV-delivered gene by delayed LPS-induced arthritis. rAAV-lacZ virus (10⁷ infectious units) was injected into both knee joints. Thirty days later, the right knees (B to E) were injected with 10 μg of LPS, and the left knees (G to J) were injected with PBS. Before treatment (A and F) or at 3 (B and G), 7 (C and H), 14 (D and I), and 30 (E and J) days after treatment, synovial membranes were surgically removed, fixed, and stained for β-galactosidase (lacZ) activity. Bar, 100 μm.