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. Author manuscript; available in PMC: 2023 Sep 2.
Published in final edited form as: N Engl J Med. 2023 Mar 2;388(9):813–823. doi: 10.1056/NEJMoa2211437

Figure 2. Forest Plot of Event-free Survival According to Subgroup.

Figure 2.

Shown are Kaplan–Meier estimates of 2‑year event‑free survival in the neoadjuvant–adjuvant and adjuvant‑only groups. The difference in 2‑year event‑free survival and 95% confidence intervals (horizontal lines) for the difference are reported. Zubrod’s performance‑status scores range from 0 to 5, with higher scores indicating greater disability; a score of 0 indicates that the patient is fully active, 1 that the patient is restricted in strenuous activity but is ambulatory, and 2 that the patient is unable to work but is ambulatory and capable of self‑care and up and about more than 50% of waking hours. Disease stages are defined according to the American Joint Committee on Cancer Cancer Staging Manual, 8th edition. The diamond represents the overall estimate, with the width of the diamond indicating the 95% confidence interval, and the horizontal lines also represent 95% confidence intervals. The sizes of the boxes are proportional to the numbers of events. LDH indicates lactate dehydrogenase.