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. 2023 Jul 26;14:1215686. doi: 10.3389/fphys.2023.1215686

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Copyright © 2023 Markota, Kalamar, Fluher and Pirkmajer.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of temperature on viral entry. The expression of viral hemagglutin is greater around 33°C compared to higher temperatures which facilitates membrane fusion and infection with influenza virus. The interaction between Spike glycoprotein and ACE2 receptor which facilitates entry of SARS-CoV-2 is enhanced at around 37°C and restricted at temperatures around 40°C.