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Two progression models for the generation of ISFN and overt B-cell lymphomas with a GC B cell phenotype. (A) In the branched or divergent evolution model, each ISFN and follicular lymphoma (FL) or DLBCL arises divergently from a shared progenitor clone harboring t(14;18). (B) In contrast, in the linear model, FL/DLBCL evolves directly from ISFN acquiring additional gene alterations.
