Table 3:
Annual rates of change in clinical measures
| Clinical Scale | Left-dominant (N=18) | Right-dominant (N=14) | Symmetric (N=6) | P-value |
|---|---|---|---|---|
| MoCA /30 | 2.0 (0.7, 2.9) | 3.5 (1.7, 7.7) | 3.3 (0.0, 7.1) | 0.25 |
| UPDRS III /180 | 8.6 (4.0, 11.0) | 14.7 (8.4, 26.5) | 14.7 (9.0, 18.9) | 0.01 |
| NPI-Q /36 | 0.3 (−0.1, 1.0) | 1.25 (0.8, 3.8) | 0 (−0.3, 3.0) | 0.11 |
| FBI total/72 | 2.0 (0.7, 3.8) | 8.0 (4.0, 10.34) | 3.25 (0.4, 11.8) | 0.009 a |
| FBI - Negative behaviors /36 | 1.5 (0.5, 2.9) | 5.0 (2.2, 7.0) | 3.25 (1.1, 7.3) | 0.01 a |
| FBI - Disinhibition /36 | 0.2 (0.0, 0.7) | 2.0 (0.8, 5.0) | 0.0 (−0.8, 4.50) | 0.02 a |
| WAB-Praxis /60 * | 1.8 (1.3, 4.5) | 6.33 (4.6, 7.0) | 4.90 (1.75, 15.25) | 0.02 a |
| WAB-AQ /100 * | 1.43 (0.4, 4.6) | 2.1 (1.1, 5.7) | 1.40 (0.4, 6.25) | 0.28 |
| NAT /10 * | 0 (−0.3, 1.7) | 1.0 (0.3, 2.0) | 0.0 (0.0, 2.0) | 0.16 |
| ASRS total score /52 | 4.3 (3.1, 7.2) | 5.1 (3.1, 6.3) | 4.8 (1.8, 9.6) | >0.99 |
| Dysarthria severity /4 | 0.1 (0.0, 0.5) | 0.3 (0.2, 0.6) | 1.0 (0.4, 1.2) | 0.05 b |
| MSD /10 * | 0.8 (0.5, 1.0) | 1.0 (0.7, 2.0) | 1.50 (0.9, 2.1) | 0.09 |
Data shown as median and interquartile range. Clinical scales shown as points change per year.
Abbreviations: Western Aphasia Battery-Aphasia Quotient (WAB-AQ), Western Aphasia Battery-Praxis (WAB-Praxis), Northwestern Anagram Test (NAT), Apraxia of Speech Rating Scale (ASRS), Unified Parkinson’s Disease Rating Scale III (UPDRS III), Montreal Cognitive Assessment (MoCA) test, Motor Speech Disorder severity (MSD), Neuropsychiatric Inventory Questionnaire (NPI-Q), Frontal Behavior Inventory (FBI).
Higher rates reflect greater decrease in raw scores
Significant difference between left-dominant and right-dominant PPAOS using Dunn’s multiple comparison test
Significant difference between left-dominant and symmetric PPAOS using Dunn’s multiple comparison test