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. 2023 Jul 31;120(32):e2309967120. doi: 10.1073/pnas.2309967120

Fig. 5.

Fig. 5.

Activin E promotes a gene signature related to adipose dysfunction. (A) Heat map of epididymal adipose transcriptome signatures comparing Inhbe overexpression, Inhbe KO on chow and high-fat diet (HFD) vs. control-treated or WT mice, respectively. (B) Dot plots showing top biological pathways for oppositely regulated genes (Inhbe overexpression vs. KO) in epididymal WAT. (C) Heatmap showing examples of oppositely regulated genes (Inhbe overexpression vs. KO) in epididymal WAT. (D) Relative gene expression levels of PPARG target genes in epididymal WAT, comparing Inhbe KO and WT mice on high-fat diet. (E) Heatmap of epididymal adipose transcriptome signatures comparing WT chow vs. HFD, and Inhbe KO vs. WT on high-fat diet (HFD), demonstrating that Inhbe LOF reverses many of the HFD effects seen in WT mice. (F) Dot plots showing top biological pathways for genes increased in epididymal WAT of Inhbe KO vs. WT on HFD.