Table 2.
Amplitude of low-frequency fluctuation (ALFF) differences between recovered COVID-19 and healthy controls (HCs)
| ROI | Brain areas | Functions of brain areass [25] | Brodmann area | MNI coordinates (X,Y,Z) mm | Number of voxels | Peak t-valuea |
|---|---|---|---|---|---|---|
| 1 | right precuneus |
visual information memory attention |
7 | 6, -69, 30 | 54 | 3.9439 |
| 2 | right middle temporal gyrus |
memory attention auditory visual processing |
39 | 51, -69, 18 | 53 | 4.2999 |
| 3 | right middle occipital gyrus | visual processing | 18/19 | 33, -87, 6 | 50 | 4.1681 |
| 4 | right inferior occipital gyrus | visual processing | - | 33, -63, -9 | 30 | 4.0042 |
| 5 | right middle frontal gyrus |
executive functioning working memory attention |
10 | 42, 51, 27 | 34 | -4.0024 |
| 6 | right inferior temporal gyrus | visual processing | 20 | 48, -21, -30 | 23 | -4.3546 |
| 7 | left inferior temporal gyrus | visual processing | 20 | -48, -18, -30 | 34 | -4.2425 |
Note: The differences in ALFF between recovered COVID-19 and HCs were performed with a two-sample t-test, and the results were FDR-corrected (P < 0.05). a Positive t-value means ALFFCOVID−19 > ALFFHC. Negative t-value means ALFFCOVID−19 < ALFFHC.
Brodmann areas of the cerebral cortex are defined by cytoarchitecture, proposed by the German anatomist Korbinian Brodmann in the early 1900’s
MNI coordinates represents the spatial coordinate position of the brain area. It refer to the normalized space defined in SPM12, which is in mm, and the (X, Y, Z) axes are oriented towards (right, anterior, posterior). The origin is at the AC (anterior commissure) point of the template, with the (negative) Y axis also going through the PC (posterior commissure) point of the template
Number of voxels represent the size of brain areas