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. 2023 Jun 26;11(6):e006166. doi: 10.1136/jitc-2022-006166

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© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

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G-MDSCs promote the differentiation of M-MDSC into M2 macrophages via exosome. (A) Total protein in GM-Exo (n=3). (B) The percentage of F4/80⁺Ly6C^low cell were detected by FACS (n=3). (C) Summary graphs of the percentage of differentiated M-MDSCs to total M-MDSCs (n=3). (D) Representative micrograph of GM-Exo. (E) The percentage of F4/80⁺Ly6C^low cell were detected by FACS (n=3). (F) Summary graphs of the percentage of differentiated M-MDSCs to total M-MDSCs (n=3). (G) Flow chart of GM-Exo-induced differentiation of M-MDSC into M2 macrophages in vivo. (H) Immunofluorescence for detecting F4/80 and GM-Exo. Images were representative of six random fields. (I) Summary graphs of the percentage of F4/80⁺CD206⁺ cells in colorectal tissues (n=6). Statistical analyses were performed using unpaired t-tests. G-MDSCs, granulocytic myeloid-derived suppressor cells; M-MDSCs, monocytic MDSCs. (*p<0.05, **p<0.01, ***p<0.001, one-way ANOVA test or unpaired t test; error bars, SD).