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. 2023 Jun 26;11(6):e006166. doi: 10.1136/jitc-2022-006166

Figure 6.

Figure 6

IL-6 promotes GM-Exo miR-93–5 p production in a JAK/STAT3-dependent manner. (A) IL-6 levels were detected by ELISA (n=6). (B) IB analysis of p-STAT3 and STAT3 in G-MDSC. (C) Summary graphs of p-STAT3 and STAT3 in G-MDSC (n=3). (D) Exosomes from G-MDSCs were quantified (n=3). (E) The relative expression of miR-93–5 p in G-MDSCs and GM-Exo was analyzed using qRT-PCR (n=3). (F) IB analysis of proteins in G-MDSCs. (G) Summary graphs of proteins (n=3). (H) The relative expression of miR-93–5 p was analyzed using qRT-PCR (n=3). (I) Schematic diagram of IL-6-mediated G-MDSC exosomal miR-93–5 p production in a JAK/STAT3-dependent manner. Statistical analyses were performed using unpaired t-tests. G-MDSCs, granulocytic myeloid-derived suppressor cells (*p<0.05, **p<0.01, ***p<0.001, ns, not significant, one-way ANOVA test or unpaired t test; error bars, SD).