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. 2023 Jun 26;11(6):e006166. doi: 10.1136/jitc-2022-006166

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© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

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Early application of anti-IL-6 Abs sensitizes CAC to STAT3 inhibitor. (A) Changes in DAI during AOM/DSS treatment (n=6). (B) Length of the colon (n=6). (C) Representative images of histological sections (n=6). (D) The relative expression of miR-93–5 p was analyzed using qRT-PCR. (n=6). (E) Percentage of CD11b⁺Gr-1⁺ cells or CD11b⁺F4/80⁺ cells in CD45⁺ cells (n=6). (F) Quantification of CD3⁺CD8⁺ cell (n=6). (G) The correlation between macrophage and IL-6 in COAD patients was determined by the Pearson’ s correlation test. (H) Analysis of the relationship between IL-6 and overall survival in COAD patients using TIDE database. Statistical analyses were performed using two-way ANOVA for DAI comparison and multiple unpaired t-tests for the remaining data.(*p<0.05, **p<0.01, ***p<0.001, ns, not significant).CAC, colitis-associated cancer; DAI, Disease Activity Index; DSS, dextran sulfate sodium; COAD, colon adenocarcinoma; AOM, azoxymethane.