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. 2023 Jun 28;11(6):e006890. doi: 10.1136/jitc-2023-006890

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© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Cellular ferrous levels might be the key to influencing cell fate in the case of alterations in PRMT5 or NRF2 protein levels. (A) Different breast cancer cell lines were transfected with PRMT5 or NRF2 plasmids and then treated with RSL3 for 24 hours. Then, an MTT assay was conducted to determine cell viability. (B) NRF2 expression-related survival curves of all patients with breast cancer or patients with triple negative breast cancer. (C) Cellular ferrous levels of a panel of breast cancer cell lines were determined using FerroOrange. Scale bar, 100 μm. Average of three experiments. *p<0.05. PRMT5, protein arginine methyltransferase 5; TNBC, triple-negative breast cancer.