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. 2023 Aug 9;42:201. doi: 10.1186/s13046-023-02778-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Effect of Ps conditioned media on PDAC growth. (A) Growth curve of HuPa4 tumors transplanted s.c and treated with HPs conditioned medium or control medium (mean ± SEM; n = 4 for each group, two-way ANOVA with Bonferroni’s multiple comparison test, *p < 0.005,**p < 0.0005, ***p < 0.0001). Ki67 immunostaining (B) and quantification of tumor cell proliferation (C) at euthanasia (400X, scale bar 100 μm) (mean ± SEM). Proliferation of MIAPaCa2 (D), BxPC3 (E), and FC1199 cells (F) in response to respectively 7 and 5 human and murine Ps CM, (72 h of treatment). Data are percentages of control from at least two different experiments (mean ± SEM; one-way ANOVA with Dunnett’s multiple comparison test, ***p < 0.001 ****p < 0.0001). (G) Proliferation of FC1199 cells in response to murine Ps CM, containing or not Langerhans islets. Data are percentages of control from at least five different Ps preparations (mean ± SEM; one-way ANOVA with Dunnett’s multiple comparison test, **p < 0.01, *p < 0.05)