Table 2.
Descriptive Summary of Clostridioides difficile Health-Related Quality-of-Life Survey Scores at Baseline and Weeks 1, 4, and 8
| Cdiff32 Domain | Cdiff32 Score, Mean (SD)a | Difference in Change From Baseline to wk 8 | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Baseline | wk 1 | wk 4 | wk 8 | ||||||
| Placebo (n = 57) |
RBL (n = 128) |
Placebo (n = 76) |
RBL (n = 168) |
Placebo (n = 61) |
RBL (n = 135) |
Placebo (n = 57) |
RBL (n = 128) |
||
| Total | 43.6 (21.3) | 44.2 (17.5) | 57.6 (21.3) | 61.6 (18.3) | 68.0 (22.4) | 71.7 (18.7) | 69.2 (24.0) | 75.8 (18.1) | 6.0 (3.4) (P = .12) |
| Physical | 50.8 (23.5) | 53.2 (21.3) | 68.2 (22.5) | 73.3 (18.4) | 74.6 (23.7) | 81.0 (17.2) | 78.0 (23.0) | 84.4 (16.7) | 4.1 (3.8) (P = .30) |
| Mental | 34.5 (21.5) | 33.0 (16.9) | 46.0 (23.1) | 48.8 (21.6) | 59.0 (24.4) | 61.5 (22.7) | 59.4 (27.3) | 66.3 (21.8) | 8.5 (3.7) (P < .05) |
| Social | 50.1 (26.8) | 53.5 (23.4) | 61.4 (26.2) | 66.1 (23.2) | 71.7 (27.5) | 75.5 (22.3) | 73.0 (28.0) | 80.1 (21.1) | 3.6 (4.4) (P = .51) |
Abbreviations: Cdiff32, Clostridioides difficile Health-related Quality-of-Life Survey; RBL, fecal microbiota, live-jslm (REBYOTA; Rebiotix).
a
The sample size at baseline was restricted to patients who also had data at week 8. The sample size at week 1 was restricted to patients with both baseline and week 1 data, and the sample size at week 4 to patients with both baseline and week 4 data.