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. Author manuscript; available in PMC: 2023 Aug 9.
Published in final edited form as: Curr Treat Options Psychiatry. 2018 Apr 17;5:195–210. doi: 10.1007/s40501-018-0145-1
Recommended dosage in older adults 5 mg [25]
Indications Sleep onset and maintenance insomnia, short-term use [25, 26]
Contraindications Hypersensitivity to zolpidem [28, 29]
Main drug interactions CNS-active drugs including imipramine, chlorpromazine, haloperidol, alcohol, sertraline, and fluoxetine; drugs that affect drug metabolism via cytochrome P450 including CYP3A4 inducers and inhibitors [29]
Main side effects Short term: drowsiness, dizziness, and diarrhea. Long term: dizziness and drugged feelings [29]
Special points Additional zolpidem compounds include zolpidem extended release (recommended dose of 6.25 mg for short-term use for sleep onset insomnia); zolpidem sublingual (Edluar; recommended dose of 5 mg for short-term use for sleep onset insomnia); zolpidem sublingual (Intermezzo®; recommended dose of 1.75 mg, as needed, to reduce latency to reinitiate sleep after nighttime awakenings, if ≥ 4 h before planned wake time [25]