Recommended dosage for older adults	Usual dose for depression in older adults: 75–150 mg; usual dose for insomnia in adults (not older adults specifically): 50–100 mg [33]
Indications	Major depressive disorder [29]; “off-label” use for management of insomnia [29,33]
Contraindications	Hypersensitivity to trazodone or any component ingredients; current or recent (past 2 weeks) use of MAOIs; linezolid or intravenous methylene blue [33]
Main drug interactions	CNS depressants; CP3A4 inhibitors or inducers; digoxin or phenytoin; warfarin [29]
Main side effects	Reported in ≥ 5% and more frequently than in those treated with placebo: somnolence/sedation, dizziness, constipation, blurred vision [29]
Special points	Trazodone is not currently approved by the FDA for the treatment of insomnia. Current AASM guidelines indicate insufficient evidence to ascertain the efficacy of trazodone in the management of chronic insomnia and recommend against its use in the treatment of sleep onset or maintenance insomnia (versus no treatment) [26••]. Geriatric patients may be at increased risk of hyponatremia, an adverse reaction documented in association with antidepressant use [29]. Antidepressants may increase the risk of suicidal thoughts and behaviors.