Table 2.
Frequency of variables used to define anti-synthetase syndrome.
| VARIABLE | VARIABLE ALONE (*EXCLUSIVE) | VARIABLE ALONE (**NOT EXCLUSIVE) | VARIABLE IN ASSOCIATION WITH OTHERS | TOTAL (Total definitions N=85) | |
|---|---|---|---|---|---|
|
Anti-synthetase
autoantibodies |
Anti-Jo1 | 0 | 0 | 0 | 67 |
| Anti-PL12 | 0 | 0 | 0 | 46 | |
| Anti-PL7 | 0 | 0 | 0 | 40 | |
| Anti-EJ | 0 | 0 | 0 | 23 | |
| Anti-OJ | 0 | 0 | 0 | 16 | |
| Anti-KS | 0 | 0 | 0 | 10 | |
| Anti-Zo | 0 | 0 | 0 | 1 | |
| Myositis | Overall definitions | 30 | 19 | 16 | 65 |
| DM/PM Bohan and Peter | 31 | ||||
| CPK | 10 | ||||
| EMG | 9 | ||||
| Biopsy | 9 | ||||
| Weakness | 8 | ||||
| Aldolase | 2 | ||||
| MRI | 2 | ||||
| Not defined/Other definitions | 21 | ||||
| ILD | Overall definitions | 14 | 19 | 16 | 49 |
| HRCT | 39 | ||||
| PFT | 23 | ||||
| Biopsy | 7 | ||||
| Clinical | 6 | ||||
| Other clinical manifestations | Arthritis/arthralgia | 1 | 14 | 11 | 26 |
| Raynaud’s phenomenon | 0 | 3 | 10 | 13 | |
| Skin manifestations | 0 | 4 | 10 | 14 | |
| Fever | 0 | 2 | 5 | 7 | |
| Mechanic’s hands | 0 | 3 | 8 | 11 | |
| Sclerodactyly | 0 | 0 | 2 | 2 |
*
EXCLUSIVE: the variable was considered sufficient and necessary for ASSD diagnosis
**
NOT EXCLUSIVE: the variable was sufficient but not necessary to make the diagnosis.
EMG: electromyography; CPK: creatine phosphokinase; DM: dermatomyositis; PM: polymyositis; MRI: magnetic resonance imaging; HRCT: high resolution computed tomography; PFT: pulmonary function tests.