Figure 7.

Preclinical study using the in vivo mouse model to demonstrate the role of AR/circ-SLCO1B7/miR-139-5p/TPD52 signaling in the lung cancer progression. In vivo imaging system (IVIS) imaging was performed to detect the presence of distal metastasis foci in mice. B. Quantification of the number of mice with metastasis. C. Quantification of the total number of metastatic foci. D. Immunohistochemistry (IHC) assay was conducted to examine TPD52 expression in tumor tissues of mice in each group. E. A schematic depiction of how AR regulated circ-SLCO1B7 contributed to lung cancer progression. All quantitations are presented as mean ± SD, and p-values were calculated using the t-test. Significance level is denoted as **p < 0.01.