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. 2023 Jun 14;224(4):iyad110. doi: 10.1093/genetics/iyad110

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Fig. 5. — Bang sensitivity and life span of the transgenic flies. a–a′) Bang sensitivity assays were performed at 5 DAE: ptub::E(z)^A691G transgenic flies in the heteroallelic null background show bang sensitivity whereas ptub::E(z)^WT flies are not bang sensitive (a, P = 0.0041). When bang sensitivity assays are carried out in the wildtype background, ptub::E(z)^A691G does not produce a significantly different bang sensitive phenotype than the wildtype ptub::E(z)^WT (a′, P = ns). Unpaired t-tests determined P-values. b–b′) Bang sensitivity performed at 16 DAE: ptub::E(z)^A691G transgenic flies in the heteroallelic null background continue to show bang sensitivity at 16 DAE when compared to ptub::E(z)^WT (b, P = 0.0004). In the wildtype background, the ptub::E(z)^A691G shows bang sensitivity when compared to ptub::E(z)^WT (b′, P = 0.0002). Unpaired t-tests determined P-values. c–c′) Life span assay: ptub::E(z)^A691G transgenic flies in the heteroallelic null background live shorter than the ptub::E(z)^WT (c, Median Survival: E(z)^WT = 47, E(z)^A691G = 35, E(z)⁷³¹ = 65, P < 0.0001). In the fly wildtype background, ptub::E(z)^A691G transgenic flies again show a similar life span defect when compared to ptub::E(z)^WT (c′, Median Survival: E(z)^WT = 58, E(z)^A691G = 51, E(z)⁷³¹ = 65, P < 0.0001). Curve comparison was used to determine P-values.