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Fig 4 and Pip4k2c in phosphoinositide biosynthesis. Phosphoinositides are localized on the cytoplasmic surface of the endolysosomal compartment. In addition to the enzymes shown here, several additional enzymes catalyze the complex interconversions between the seven naturally occuring phosphoinositides (Hasegawa et al. 2017; Palamiuc et al. 2019). The abundance of the diphosphoinositide PI(3,5)P2 is reduced by inactivation of Fig 4 and increased by inactivation of Pip4k2c.
