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. 2023 Jul 24;14:1004245. doi: 10.3389/fendo.2023.1004245

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Copyright © 2023 Liu, Wei, Wang, Liu, Zhang, Liu, Liu and Ye

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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WGCNA results of 112 ovarian tissue samples. (A) To fit the network to a scale-free distribution, a soft threshold of 4 was chosen. (B) Twenty-nine co-expressed regulatory modules were obtained with an overhang fusion distance of 0.25. (C) Heatmap of Module-trait relationships. From the figure, it can be found that magenta, lightcyan modules are related to the 40-49 age group, while darkgrey, lightcyan and salmon modules are related to the 30-39 age group. (D) The gene set consisting of 29 modules of hub genes (R>0.3, p<0.001) was mapped to single-cell sequencing data by the ssGSEA algorithm. We focused on comparing the enrichment scores of darkgrey, lightcyan, magenta, and salmon on four modules in 14 cell types. (E) KEGG enrichment results of the 21-module hub genes. Eight of the 29 modules were not enriched for a statistically significant signaling pathway (p.adjust<0.05).