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. 2023 Jul 19;14:1165360. doi: 10.3389/fmicb.2023.1165360

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Copyright © 2023 Chen, Wu, Zhang and Zhao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Microbiota composition in responders (n = 26) and non-responders (n = 28). (A) Summary of the relative abundances of phyla present in the study population. (B) Log2 abundance of Verrucomicrobiota. Verrucomicrobiota were significantly elevated in non-responders compared with responders. Statistically significant differences according to the MetaStat are marked with asterisks. ***p < 0.001, **p < 0.01, and *p < 0.05. (C) Summary of the relative abundances of bacterial genera detected in responders and non-responders. (D) Genus-level bacteria that were significantly different between the responders and non-responders. Statistical analysis was performed by the t-test. (E) Histogram of LDA scores to identify differential abundant bacteria between responders and non-responders (LDA score > 3). (F) Cladogram generated from the LEfSe analysis indicating the phylogenetic distribution from class to species of the gut microbiota of responders and non-responders.