Resource Table:

Unique stem cell lines identifier	NIAi002-A NIAi002-A-1 NIAi002-A-2 NIAi002-A-3 NIAi003-A NIAi003-A-1 NIAi003-A-2 NIAi003-A-3
Alternative names of stem cell lines	A53T SNCA 40760 (NIAi002-A) Iso-WT SNCA 40760 PL1E11 (NIAi002-A-1) Iso-WT SNCA 40760 PL3B3 (NIAi002-A-2) Iso-WT SNCA 40760 PL3B7 (NIAi002-A-3) A53T SNCA 42720 (NIAi003-A) Iso-WT SNCA 42720 PL2B9 (NIAi003-A-1) Iso-WT SNCA 42072 PL2C11 (NIAi003-A-2) Iso-WT SNCA 42072 PL3G1 (NIAi003-A-3)
Institution	National Institutes of Health, National Institute on Aging
Contact information of distributor	Mark R Cookson: cookson@mail.nih.gov
Type of cell lines	iPSC
Origin	Human
Cell Source	The Michael J. Fox Foundation for Parkinson’s Research (MJFF), Parkinson’s Progression Markers Initiative (PPMI).
Clonality	Clonal
Method of reprogramming	Sendai virus
Multiline rationale	Isogenic clones from two unrelated donors carrying the same pathogenic variant in a PD related gene
Gene modification	Yes
Type of modification	Revert SNCA p.A53T to WT sequence
Associated disease	Parkinson’s disease
Gene/locus	SNCA/PARK1
Method of modification	RNP CRISPR/Cas9
Name of transgene or resistance	N/A
Inducible/constitutive system	N/A
Date archived/stock date	N/A
Cell line repository/bank	Indiana University https://hpscreg.eu/cell-line/NIAi002-A https://hpscreg.eu/cell-line/NIAi002-A-1 https://hpscreg.eu/cell-line/NIAi002-A-2 https://hpscreg.eu/cell-line/NIAi002-A-3 https://hpscreg.eu/cell-line/NIAi003-A https://hpscreg.eu/cell-line/NIAi003-A-1 https://hpscreg.eu/cell-line/NIAi003-A-2 https://hpscreg.eu/cell-line/NIAi003-A-3
Ethical approval	Original line obtained from MJFF. Ethical licence/Sponsor Protocol number: 001.