Table 6. Adverse Events related to Musculoskeletal System.
OD - Once Daily, BID - Twice Daily
| Study | Increased blood creatine kinase level, n (%) | Back Pain, n (%) | Arthralgia, n (%) | Neck Pain, n (%) | Musculoskeletal pain, n (%) | Muscle strain, n (%) |
|---|---|---|---|---|---|---|
| Ankrom et al.9 | ||||||
| 60 mg OD | - | 2 (7.7) | - | - | - | - |
| Goadsby et al.10 | ||||||
| 10 mg OD | 4 (4) | - | - | - | - | - |
| 30 mg OD | 3 (2) | - | - | - | - | - |
| 60 mg OD | 2 (1) | - | - | - | - | - |
| 30 mg BID | 6 (7) | - | - | - | - | - |
| 60 mg BID | 2 (2) | - | - | - | - | - |
| Placebo | 3 (2) | - | - | - | - | - |
| Min et al.11 | ||||||
| 170 mg | - | 3 (13.0) | - | 2 (8.7) | 2 (8.7) | - |
| Placebo | - | 0 | - | 0 | 0 | - |
| Ailani et al.13 | ||||||
| 10 mg OD | 5 (2.3) | - | - | - | - | - |
| 30 mg OD | 2 (0.9) | - | - | - | - | - |
| 60 mg OD | 7 (3.0) | - | - | - | - | - |
| Placebo | 2 (0.9) | - | - | - | - | - |
| Klein et al.16 | ||||||
| 60 mg OD | - | 17 (2.5) | 15 (2.2) | - | - | - |
| Ashina et al.17 | ||||||
| 60 mg OD | - | 13 (2.4) | 11 (2.0) | - | - | 11 (2.0) |