Table 7. Anti-snake venom sera availability [26–28].
S. No. | Type of antivenom | Manufacturer | Country of origin | Status of production currently | Snake species | Comment |
---|---|---|---|---|---|---|
1 | FAV-Afrique | Sanofi Pasteur | France | Discontinued in January 2014. Last batch expired in Jan 2016 | 10 species of the Elapidae and Viperidae families | The most highly effective in treating envenoming by Echis ocellatus, the West African saw-scaled viper that causes great morbidity and mortality throughout the West and Central African savannah MicroPharm Limited acquired product in 2018 and seeking to re-launch it |
2 | SAIMR Polyvalent Antivenom | South African Vaccine Producers |
South Africa | Active production |
B. arietans, B. gabonica, D. angusticeps, D. jamesoni, D. polylepis, H. haemachatus, N. annulifera, N. melanoleuca, N. mossambica, N. nivea |
Considered as the current “Gold Standard” for treating envenomings by many African snake species |
3 | Antivipmyn Africa | Instituto Bioclon / Silanes | Mexico | Active production |
B. arietans, B. gabonica, B. rhinoceros, D. angusticeps, D. jamesoni, D. polylepis, D. viridis, E. leucogaster, E. ocellatus, E. pyramidum, N. haje, N. katiensis, N. melanoleuca, N. nigricollis, N. nivea |
|
4 | Bivalent Naja / Walterinnesia Snake Antivenom | National Antivenom and Vaccine Production Centre | Saudi Arabia | Active production |
N. arabica N. haje N. melanoleuca N. naja N. nigricollis N. nivea Walterinnesia aegyptia Walterinnesia morgani |
|
5 | Pan-African antivenom (EchiTAb-Plus-ICP) | Instituto Clodomiro Picado (ICP) University of Costa Rica |
Costa Rica | Active production |
B. arietans, E. ocellatus, N. nigricollis D. polylepis) N. mossambica N. annulifera H. haemachatus |
Intact IgG The expanded-scope EchiTAb + ICP has lower ability to neutralize the venom of B. arietans, but similar ability to neutralize the venoms of D. polylepis, N. mossambica and H. haemachatus When compared to FAV Afrique and the SVA African antivenoms |
6 | Snake Venom Antiserum | Bharat Serums & Vaccines | India |
B. caeruleus N. haje |
||
7 | Inoserp Pan-Africa | Inosan Biopharma | Mexico | Active production |
E. ocellatus, E. leucogaster, E. pyramidum, B. arietans, B. rhinoceros, B. nasicornis, B. gabonica D. polylepis, D. viridis, D. angusticeps, D. jamesoni, N. nigricollis, N. melanoleuca, N. haje, N. pallida N. nubiae, N. katiensis N. senegalensis. |
Lyophilized Polyvalent F(ab’)2 Immunoglobulin Fragments (Equine) |
8 | Favirept Polyvalent Snake Antivenin | Sanofi Pasteur | France | Discontinued |
B. arietans C. cerastes D. deserti E. leucogaster N. nigricollis, N. melanoleuca, N. haje, |
|
9 | SII Polyvalent Antisnake (Snake Antivenom Seum IP) |
Serum Institute of India | India | Active production |
N. naja E. carinatus D. russelii B. caeruleus |
Polyvalent equine antivenom |
10 | SAIMR Echis Antivenom | South African Vaccine Producers |
South Africa | Active production |
E. carinatus, E. ocellatus, E. coloratus, Cerastes spp. |
|
11 | EchiTAbG | MicroPharm | United Kingdom | Active production | Echis ocellatus | |
12 | SAIMR Boomslang Antivenom | South African Vaccine Producers |
South Africa | Active production | Dispholidus typus | |
13 | Snake Venom Antiserum (African) (AFRIVEN-10) |
VINS Bioproducts | India | In active production |
B. arietans, B. gabonica, E. ocellatus, E. leucogaster, N. haje, N. melanoleuca, N. nigricollis, D. polylepis, D. viridis, D. jamesoni. |
Lyophilized powder Polyvalent, enzyme-refined equine antivenom immunoglobulin fragments |
14 | Snake Venom Antiserum (Pan African) (PANAF-Premium) |
Premium Serums and Vaccines | India | In active production |
B. arietans, B. gabonica, B. nasicornis, B. rhinoceros D. angusticeps, D. jamesoni, D. polylepis, D. viridis, E. carinatus, E. leucogaster, E. ocellatus, N. nigricollis, N. haje, N. melanoleuca |
Lyophilized powder Polyvalent, enzyme-refined equine antivenom immunoglobulins |
15 | Anti-Snake Venom Serum Pan Africa [10] BEAFRIQUE-10 |
M/s. Biological E | India | In active production |
B. arietans, B. gabonica, E. ocellatus, E. leucogaster, N. haje, N. melanoleuca, N. nigricollis, D. polylepis, D. viridis, D. jamesoni. |
Liquid, Polyvalent, Enzyme refined, Equine F(ab’) immunoglobulin |